N1-甲基-假尿苷三磷酸 N1-Methylpseudo-UTP

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N1-甲基-假尿苷三磷酸，mRNA疫苗研究爆品

N1-甲基假尿苷（N1-Methylpseudouridine）是一种修饰核苷，用于增强 mRNA 翻译。将N1-甲基假尿苷掺入 mRNA可关闭免疫/eIF2α 磷酸化依赖性翻译抑制，并增加mRNA上的核糖体的密度，从而显着促进翻译过程。N1-甲基假尿苷在翻译能力方面优于其他几种修饰的核苷和相应的组合。

辉瑞Pfizer-BioNTech和莫德纳Moderna开发的COVID-19 mRNA疫苗证明了N1-甲基假尿苷修饰在mRNA疫苗开发中的出色成果，其中尿苷在两种mRNA疫苗中完全被N1-甲基假尿苷取代。N1-甲基假尿苷修饰的RNA的制备是通过T7 RNA 聚合酶介导的体外转录酶促掺入相应的N1-甲基假尿苷三磷酸（N1-Methylpseudo-UTP）来进行的。

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货号	产品名称	描述
NU-890	N1-Methylpseudo-UTP, Sodium salt	用于相关研发使用纯度(HPLC): ≥ 95 % 浓度：100 mM - 110 mM 规格：10 μl (100 mM)/5 x 10 μl (100 mM)
NU-890-THR	N1-Methylpseudo-UTP, Sodium salt	用于mRNA生产，提供ml至L规格纯度(HPLC): ≥ 99 % 额外检测：功能性、DNAse/RNAse、蛋白酶、内毒素起始材料和生产无动物源成分
RNT-107	HighYield T7 mRNA Synthesis Kit me1Ψ-UTP	用于N1-甲基假尿苷修饰(m)RNA的合成规格：15 reactions x 20 μl/50 reactions x 20 μl 每个反应产生约100-130 μg N1-甲基假尿苷修饰的RNA
RNT-115	HighYield T7 ARCA mRNA Synthesis Kit me1Ψ-UTP	用于ARCA加帽和N1 甲基假尿苷修饰 (m) RNA的合成规格：15 reactions x 20 μl/50 reactions x 20 μl 20 μl反应产生约30-50 μg RNA

mRNA合成原料

货号	产品名称	规格	CAS号
NU-852S NU-852L	m7GP3G (Monomethylated Cap Analog)	10 μl (100 mM) 5 x 10 μl (100 mM)	62828-64-2(acid)
NU-855S NU-855L	m2 7,3'-O GP₃G (ARCA Cap Analog)	10 μl (100 mM) 5 x 10 μl (100 mM)	400806-46-4 (acid) 400806-60-2(Trisodium salt)
NU-1138S NU-1138L	5-Methyl-CTP	10 μl (100 mM) 5 x 10 μl (100 mM)	327174-86-7 (acid)
NU-988S NU-988L	N4-Acetyl-CTP	10 μl (100 mM) 5 x 10 μl (100 mM)	N/A
NU-1139S NU-1139L	Pseudo-UTP	10 μl (100 mM) 5 x 10 μl (100 mM)	1175-34-4
NU-972S NU-972L	5-Methoxy-UTP	10 μl (100 mM) 5 x 10 μl (100 mM)	N/A
NU-1151S NU-1151L	2-Thio-UTP	10 μl (100 mM) 5 x 10 μl (100 mM)	35763-29-2
NU-1101S NU-1101L	N6-Methyl-ATP	10 μl (100 mM) 5 x 10 μl (100 mM)	3130-39-0 (acid)
NU-1010	ATP - Solution	1 ml (100 mM)	987-65-5
NU-1011	CTP - Solution	1 ml (100 mM)	36051-68-0
NU-1012	GTP - Solution	1 ml (100 mM)	36051-31-7
NU-1013	UTP - Solution	1 ml (100 mM)	19817-92-6
NU-1014S NU-1014L	NTP Bundle (ATP, CTP, GTP, UTP)	4 x 200 μl (4 x 20 μmol) 4 x 1 ml (4 x 100 μmol)
RNT-008	T7 RNA Polymerase HC	50 μl (2 μg/μl)
RNT-018	T7 P&L RNA Polymerase HC	50 μl (2 μg/μl)
RNT-019	T7 3M RNA Polymerase HC	50 μl (2 μg/μl)

RNA合成试剂盒

货号	产品名称	规格
RNT-101	HighYield T7 RNA Synthesis Kit	50 reactions x 20 μl
RNT-201	HighYield T7 P&L RNA Synthesis Kit	50 reactions x 20 μl

mRNA合成试剂盒

货号	产品名称
RNT-004	Poly(A) Tailing Enzyme Testkit
RNT-101	HighYield T7 RNA Synthesis Kit
RNT-102	HighYield T7 ARCA mRNA Synthesis Kit
RNT-103	HighYield T7 ARCA mRNA Synthesis Kit (m5CTP/Ψ-UTP)
RNT-104	HighYield T7 mRNA Synthesis Kit (m5CTP/Ψ-UTP)
RNT-106	HighYield T7 mRNA Synthesis Kit (Ψ-UTP)
RNT-107	HighYield T7 mRNA Synthesis Kit (me1Ψ-UTP)
RNT-108	HighYield T7 mRNA Synthesis Kit (5moUTP)
RNT-109	HighYield T7 mRNA Synthesis Kit (s2UTP)
RNT-110	HighYield T7 mRNA Synthesis Kit (m5CTP)
RNT-111	HighYield T7 mRNA Synthesis Kit (ac4CTP)
RNT-112	HighYield T7 mRNA Synthesis Kit (m6ATP)
RNT-113	HighYield T7 mRNA Synthesis Kit (m1ATP)
RNT-114	HighYield T7 ARCA mRNA Synthesis Kit (Ψ-UTP)
RNT-115	HighYield T7 ARCA mRNA Synthesis Kit (me1Ψ-UTP)
RNT-116	HighYield T7 ARCA mRNA Synthesis Kit (5moUTP)
RNT-117	HighYield T7 ARCA mRNA Synthesis Kit (s2UTP)
RNT-118	HighYield T7 ARCA mRNA Synthesis Kit (m5CTP)
RNT-119	HighYield T7 ARCA mRNA Synthesis Kit (ac4CTP)
RNT-120	HighYield T7 ARCA mRNA Synthesis Kit (m6ATP)
RNT-121	HighYield T7 ARCA mRNA Synthesis Kit (m1ATP)

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